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AZD 5597
CAS No. 924641-59-8
AZD 5597( AZD5597 | AZD-5597 )
Catalog No. M16626 CAS No. 924641-59-8
A highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 290 | Get Quote |
|
| 10MG | 464 | Get Quote |
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| 25MG | 754 | Get Quote |
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| 50MG | 1044 | Get Quote |
|
| 100MG | 1404 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAZD 5597
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM.
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DescriptionA highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM, demonstrates anticancer activity in SW620 tumour xenograft, possesses suitable physiochemical and pharmacokinetic profiles for intravenous (i.v.) dosing.
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In Vitro——
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In Vivo——
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SynonymsAZD5597 | AZD-5597
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number924641-59-8
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Formula Weight437.513
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Molecular FormulaC23H28FN7O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (228.57 mM)
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SMILESO=C(C1=CC=C(NC2=NC=C(F)C(C3=CN=C(C)N3C(C)C)=N2)C=C1)N4C[C@@H](NC)CC4
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Chemical Name(S)-(4-((5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jones CD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.
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